Subclinical optic neuritis in neuromyelitis optica.


cluded that OCT could not be used to differentiate individuals with congenitally crowded optic nerves from individuals with mild papilledema. Conversely, Johnson et al (4) argued that OCT could be used to differentiate optic disc edema from optic nerve head drusen, but these authors included subjects with disc edema that was “mild, moderate, and severe” and drusen that were both visible and buried. These authors also included subjects with papilledema, ischemic optic neuropathy, and optic neuritis in their study population. Lee et al (5) claimed that spectral domain OCT may be used to differentiate optic disc edema from optic nerve head drusen, but they also included subjects in whom the edema ranged from “subtle to severe,” and did not state the etiology of the disc edema in their subjects. In the study by Sarac et al, the optic nerve head drusen group contained eyes with both visible and buried drusen. The optic disc edema group was also heterogeneous, containing subjects with “subtle to severe” optic nerve swelling. In addition, the optic disc edema group contained subjects with papilledema, nonarteritic anterior ischemic optic neuropathy, and optic neuritis. However, most clinicians would have no difficulty distinguishing a patient with optic nerve head drusen from a patient with anterior ischemic optic neuropathy or optic neuritis. We do not dispute the results reported by Sarac et al. Our concern is that clinicians reading this article will inappropriately extrapolate these conclusions to clinical care. When faced with a patient in whom the differential diagnosis includes mild optic disc edema and buried optic nerve head drusen, the guidelines proposed by Sarac et al may not hold. Their study population was not relevant to the clinical question being asked. Currently, it appears that the conclusions reached by Karam and Hedges (3) still hold. Until a study is designed with a clinically relevant population of subjects, the question of the utility of OCT in the differential diagnosis of optic disc edema and optic nerve head drusen remains unanswered.

DOI: 10.1097/WNO.0b013e3182893dd1

2 Figures and Tables

Cite this paper

@article{Aksoy2013SubclinicalON, title={Subclinical optic neuritis in neuromyelitis optica.}, author={D{\"{u}rdane Aksoy and Erkan Gokçe and Semiha Kurt and Betul Cevik and Helin Deniz Demir}, journal={Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society}, year={2013}, volume={33 2}, pages={205-7} }