Subclinical myocardial dysfunction in multiple sclerosis patients remotely treated with mitoxantrone: evidence of persistent diastolic dysfunction.

Abstract

BACKGROUND Mitoxantrone is an effective disease-modifying therapy in multiple sclerosis (MS), but its use is limited by cardiotoxicity. We evaluated global myocardial function, including myocardial performance index (MPI), on echocardiography in MS patients after remote mitoxantrone treatment. METHODS AND RESULTS Consecutive patients (n = 50) treated with… (More)
DOI: 10.1016/j.cardfail.2013.06.003

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