Subclinical hypothyroidism and Down's syndrome; studies on myocardial structure and function.

  title={Subclinical hypothyroidism and Down's syndrome; studies on myocardial structure and function.},
  author={Evelina Toscano and Giuseppe Pacileo and G Gianna Giovamma Limongelli and Marina Verrengia and Onorina Di Mita and Salvatore Di Maio and Margherita Salerno and Eleanora Del Giudice and B Caniello and Raffaele Calabr{\'o} and Generoso Andria},
  journal={Archives of disease in childhood},
  volume={88 11},
BACKGROUND The management of subclinical hypothyroidism (SH) is still controversial, as the benefit to risk ratio of prolonged L-thyroxine therapy is not clear cut. Some authors have shown abnormalities of myocardial function and structure in adults with SH, which could be reversed by L-thyroxine therapy. As SH frequently affects children with Down's syndrome (DS), and almost one half of these are affected by congenital heart disease, a concomitant SH related impairment of cardiac function… CONTINUE READING

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