Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities.

  title={Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities.},
  author={Brian D. Ross and Sinead Jacobson and Federico G. Villamil and Jacob Korula and Roland Kreis and Thomas Ernst and Truda K. Shonk and Rex A. Moats},
  volume={193 2},
PURPOSE To determine whether hydrogen-1 magnetic resonance (MR) spectroscopy of the brain allows detection of subclinical hepatic encephalopathy (SCHE). MATERIALS AND METHODS In a double-blind study, overt hepatic encephalopathy (HE) and SCHE (defined with clinical and neuropsychiatric tests) were compared by means of H-1 MR spectroscopic criteria--reduction in cerebral myo-inositol (< 2 standard deviations [SDs] from normal) and choline (< 2 SDs from normal) with or without increased… Expand

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