Subclinical central inflammation is risk for RIS and CIS conversion to MS

@article{Rossi2015SubclinicalCI,
  title={Subclinical central inflammation is risk for RIS and CIS conversion to MS},
  author={Silvia Rossi and Caterina Motta and Valeria Studer and Giulia Macchiarulo and Giorgio Germani and Annamaria Finardi and Roberto Furlan and Gianvito Martino and Diego Centonze},
  journal={Multiple Sclerosis Journal},
  year={2015},
  volume={21},
  pages={1443 - 1452}
}
Background: Subtle diffuse intrathecal inflammation is undetectable by conventional neuroimaging, and could influence multiple sclerosis (MS) disease course. Objective: To explore the role of subclinical persisting intrathecal inflammation in radiologically isolated syndrome (RIS) or clinically isolated syndrome (CIS) conversion to MS, and in early MS disease reactivation. Methods: One-hundred ninety-three subjects with RIS, CIS, relapsing–remitting (RR), or primary progressive (PP) MS were… 

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