Subclinical Leishmania infection in patients with rheumatic diseases under biological drugs

  title={Subclinical Leishmania infection in patients with rheumatic diseases under biological drugs},
  author={Martina Maritati and Alessandro Trentini and Grégory Michel and Tiziana Bellini and Shawgi Hago Almugadam and Stefania Hanau and Marcello Govoni and Pierre Marty and Carlo Contini},
PurposeClimate changes and immunosuppression are influencing the spread of leishmaniasis and re-emergence in Northern Italy, respectively. We evaluated the prevalence of subclinical leishmaniasis in patients from a Northern Italian region with chronic inflammatory rheumatism (CIRD) receiving biological drugs (BD) and correlated it to the area of residence.MethodsDNA from PBMC of patients affected by CIRD treated with either BD for at least 5 years (Group A) or other immunosuppressive drugs… 
Asymptomatic Leishmania infection in blood donors from the Southern of Spain
Asymptomatic leishmanial infection among blood donors is frequent in the Granada Province, south of Spain and the presence of livestock in this region is related to this infection, perhaps influencing vector density of this disease.
Leishmaniasis in the United States: Emerging Issues in a Region of Low Endemicity
Climate change, the identification of competent vectors and reservoirs, a highly mobile populace, significant population groups with proven exposure history, HIV, and widespread use of immunosuppressive medications and organ transplant all create the potential for increased frequency of leishmaniasis in the U.S.
Arginase/nitric oxide modifications using live non-pathogenic Leishmania tarentolae as an effective delivery system inside the mammalian macrophages
This work suggests that L. tarentolae expressing IP-10 cause specific effects on the metabolic pathways of the macrophage host, which might enable the host cells in killing of parasites and decreasing the survival of them against Leishmania infection.
Impacto de un brote de leishmaniasis en población inmunosuprimida no VIH
Tesis Doctoral leida en la Universidad Rey Juan Carlos de Madrid en 2018. Director de la Tesis: Juan Victor San Martin Lopez
Ambient Temperature and Subsequent COVID-19 Mortality in the OECD Countries and Individual United States
Background: Epidemiological studies have yielded conflicting results regarding climate and incident SARS-CoV-2 infection, and seasonality of infection rates is


Leishmaniasis in immunosuppressed individuals.
The leishmaniasis burden in immunosuppressed individuals will probably continue to rise, warranting increased awareness and enhanced surveillance systems.
Cryptic Leishmania infantum infection in Italian HIV infected patients
Assessment of the prevalence of asymptomatic L. infantum infection in HIV infected patients and a possible correlation between Leishmania parasitemia and HIV infection markers suggested suggest a relationship between high HIV viral load and high parasitemic burden.
Epidemiology of Imported Leishmaniasis in Italy: Implications for a European Endemic Country
Given the relatively low incidence of leishmaniasis importation, the risk of introduction of exotic parasites appears limited, although the detection of anthroponotic species requires attention.
Asymptomatic Leishmania infantum Infection in an Area of Northwestern Italy (Piedmont Region) Where Such Infections Are Traditionally Nonendemic
The detection of a high seroprevalence rate, confirmed as asymptomatic infection by PCR in more than half of the cases, among healthy residents in a continental area of northwestern Italy makes local L. infantum transmission very likely.
[Which screening for Leishmania infantum in asymptomatic blood donors?].
  • G. Tordini, C. Puttini, G. Zanelli
  • Medicine
    Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive
  • 2011
Through the techniques used, it was unable to confirm the presence of leishmania in the blood of the subjects studied, and the choice of the diagnostic protocol in blood donors remains an open issue as molecular analysis (kDNA) seems to suggest, in the authors' experience, limits of specificity.
Immunologic tests in patients after clinical cure of visceral leishmaniasis.
It is concluded that serological tests for kala-azar might continue to be positive after treatment of the disease, although this does not indicate a poor prognosis or a poor therapeutic response.
Leishmania infantum leishmaniasis in corticosteroid – treated patients
Physicians should recognise CS-treated patients as a population likely to be immunesuppressed and foster the risk of a diagnostic delay and of poor response to therapy in immunodeficiency conditions.
Tumor necrosis factor alpha antagonist drugs and leishmaniasis in Europe.
Clinicians may want to consider observations, which suggest that etanercept should be favoured over anti-TNF monoclonal antibodies in individuals living in or visiting areas endemic for leishmaniasis until evidence from prospective research is available.
Detection of Chlamydophila pneumoniae in patients with arthritis: significance and diagnostic value
The combined use of culture and molecular tools increases detection rates and improves the overall sensitivity, suggesting their potential use to detect C. pneumoniae may have a role as triggering factor also in chronic arthritides including AS.
Visceral leishmaniasis causes fever and decompensation in patients with cirrhosis
All patients with cirrhosis admitted for decompensation and fever lasting more than 1 week, unresponsive to broad-spectrum antibiotics, underwent diagnostic procedures for VL, and three consecutive cases of bacterial infection observed in the same period were enrolled.