Subclinical Hypothyroidism and Pregnancy Outcomes

@article{Casey2005SubclinicalHA,
  title={Subclinical Hypothyroidism and Pregnancy Outcomes},
  author={B. Casey and J. Dashe and C. E. Wells and D. McIntire and W. Byrd and K. Leveno and F. Cunningham},
  journal={Obstetrics \& Gynecology},
  year={2005},
  volume={105},
  pages={239-245}
}
BACKGROUND: Clinical thyroid dysfunction has been associated with pregnancy complications such as hypertension, preterm birth, low birth weight, placental abruption, and fetal death. The relationship between subclinical hypothyroidism and pregnancy outcomes has not been well studied. We undertook this prospective thyroid screening study to evaluate pregnancy outcomes in women with elevated thyrotropin (thyroid-stimulating hormone, TSH) and normal free thyroxine levels. METHODS: All women who… Expand
First trimester thyroid stimulating hormone as an independent risk factor for adverse pregnancy outcome
TLDR
Subclinical hypothyroidism is associated with an increased risk for preterm delivery prior to 34 gestational weeks and may also have a role in adverse pregnancy outcome – low birth weight and placental abruption – although this needs to be further explored. Expand
High prevalence of thyroid dysfunction in pregnant women
TLDR
The high prevalence of hypothyroidism observed in this study suggests that accurate thyroid screening with trimester specific reference ranges should be warranted, particularly in areas with mild to moderate iodine deficiencies. Expand
Preconception thyroid-stimulating hormone and pregnancy outcomes in women with hypothyroidism.
TLDR
The majority of women with hypothyroidism do not achieve the recommended preconception and early gestation serum thyroid-stimulating hormone (TSH) level of <2.5 mU/L, and a TSH level above this threshold was not associated with adverse fetal and maternal outcomes. Expand
Incidence of Subclinical Hypothyroidism and Hypothyroidism in Early Pregnancy.
TLDR
High-risk screening is not useful in predicting which women are at risk of thyroid disease in early pregnancy since ∼10% of women with SCH or hypothyroidism could not be diagnosed in this way. Expand
Subclinical Hypothyroidism and Isolated Hypothyroxinemia during Pregnancy and Their Association with Pregnancy Outcome: A 2-Year Study
TLDR
It is found that subclinical hypothyroidism was not associated with birth weight, week of labor, or history of miscarriages, and hypothyroxinemia was associated with high birth weight. Expand
Subclinical hypothyroidism in pregnancy and outcomes
TLDR
Screening for subclinical hypothyroidism has to be included as a routine screening test and should be treated accordingly to improve maternal and fetal outcomes. Expand
Subclinical Hypothyroidism and Its Effect on Pregnancy Outcome
A prospective analytical study was done on Eight hundred sixty nine antenatal women with singleton pregnancy at 36-38 weeks of gestation. Apart from history taking and examination maternal serum TSHExpand
Diagnosis and management of subclinical hypothyroidism in pregnancy
TLDR
O Ongoing prospective trials that are evaluating the impact of levothyroxine therapy on adverse outcomes in the mother and fetus in women with subclinical hypothyroidism will provide crucial data on the role of thyroid hormone replacement in pregnancy. Expand
Effects of Subclinical Hypothyroidism on Maternal and Perinatal Outcomes during Pregnancy: A Single-Center Cohort Study of a Chinese Population
TLDR
It is indicated that pregnant women with SCH had increased risks of GH and PROM, and their fetuses and infants had increased risk of IUGR and LBW, and routine maternal thyroid function testing is necessary to improve maternal and perinatal outcomes. Expand
Subclinical Hyperthyroidism and Pregnancy Outcomes
TLDR
Evaluated pregnancy outcomes in women with suppressed thyroid-stimulating hormone (TSH) and normal free thyroxine (fT4) levels indicated that identification of subclinical hyperthyroidism and treatment during pregnancy is unwarranted. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
Maternal thyroid deficiency and pregnancy complications: implications for population screening
TLDR
From the second trimester onward, the major adverse obstetrical outcome associated with raised TSH in the general population is an increased rate of fetal death, which would be another reason to consider population screening. Expand
Perinatal outcome in hypothyroid pregnancies
TLDR
Normalization of thyroid function tests may prevent gestational hypertension and its attendant complications in hypothyroid patients. Expand
Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.
TLDR
Undiagnosed hypothyroidism in pregnant women may adversely affect their fetuses; therefore, screening for thyroid deficiency during pregnancy may be warranted. Expand
Hypothyroidism Complicating Pregnancy
TLDR
For comparison of the incidence and perinatal results, the experience with hypothyroidism at the Mercy Hospital for Women, Melbourne, for the 10 years, 1980–1989 is reviewed. Expand
The Colorado thyroid disease prevalence study.
TLDR
The results confirm that thyroid dysfunction is common, may often go undetected, and may be associated with adverse health outcomes that can be avoided by serum TSH measurement. Expand
Subclinical Hypothyroidism
TLDR
Therapy for milder forms of hypothyroidism is controversial and the controversy surrounding therapy will not be resolved until more randomized studies are available for the subgroup of patients with TSH <10 mIU/L, and until the question of cardiovascular risk factors is further clarified. Expand
Birth weight in relation to morbidity and mortality among newborn infants.
TLDR
Mortality and morbidity are increased among infants born at term whose birth weights are at or below the 3rd percentile for their gestational age, and these differences persisted after adjustment for the mother's race and parity and the infant's sex. Expand
Subclinical thyroid disease: scientific review and guidelines for diagnosis and management.
TLDR
The strength of the evidence that untreated subclinical thyroid disease is associated with clinical symptoms and adverse clinical outcomes was assessed and recommendations for clinical practice developed and insufficient evidence to support population-based screening was found. Expand
Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy
Maternal thyroid function during early pregnancy is an important determinant of early fetal brain development because the fetal thyroid is unable to produce any T4 before 12–14 weeks' gestation.Expand
Recurrence of Mild Malformations and Dysplasias
TLDR
Women delivering infants with mild malformations involving the skin and digits of the infant are at increased risk for recurrence during their next pregnancy. Expand
...
1
2
3
...