Subclinical GvHD in non-irradiated F1 hybrids: severe lymphoid-tissue GvHD causing prolonged immune dysfunction

@article{Sprangers2011SubclinicalGI,
  title={Subclinical GvHD in non-irradiated F1 hybrids: severe lymphoid-tissue GvHD causing prolonged immune dysfunction},
  author={B. Sprangers and B. Wijmeersch and A. Luyckx and X. Sagaert and B. Verbinnen and O. Rutgeerts and C. Lenaerts and T. Tousseyn and B. Dubois and M. Waer and A. Billiau},
  journal={Bone Marrow Transplantation},
  year={2011},
  volume={46},
  pages={586-596}
}
GvHD is an important complication of allogeneic hematopoietic SCT. Parent-in-F1 models are frequently used to study GvHD immunobiology; the characteristics of parent-in-F1 GvHD vary between strain combinations and induction protocols. Here, we observed that a high-dose challenge of non-irradiated B6DBA2F1 and B6SJLF1 recipients with C57BL/6 splenocytes left the majority of recipients clinically healthy, while inducing progressive high-grade donor T-cell chimerism. We investigated this… Expand
Myeloid-derived suppressor cells in transplantation tolerance induction.
The roles of myeloid-derived suppressor cells in transplantation
The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity
...
1
2
...

References

SHOWING 1-10 OF 38 REFERENCES
Revisiting graft-versus-host disease models of autoimmunity: new insights in immune regulatory processes.
  • W. Murphy
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2000
Allogeneic bone marrow transplantation in models of experimental autoimmune encephalomyelitis: evidence for a graft-versus-autoimmunity effect.
...
1
2
3
4
...