Subclinical CNS Inflammation as Response to a Myelin Antigen in Humanized Mice

@article{Zayoud2013SubclinicalCI,
  title={Subclinical CNS Inflammation as Response to a Myelin Antigen in Humanized Mice},
  author={Morad Zayoud and Khalifa El Malki and Katrin B. M. Frauenknecht and Bettina Trinschek and Luise Kloos and Khalad Karram and Florian Wanke and Julia Georgescu and Udo F. Hartwig and Clemens J. Sommer and Helmut Jonuleit and Ari Waisman and Florian C. Kurschus},
  journal={Journal of Neuroimmune Pharmacology},
  year={2013},
  volume={8},
  pages={1037-1047}
}
Multiple sclerosis is a demyelinating autoimmune disease of the CNS. Its animal model experimental autoimmune encephalomyelitis is commonly induced by active immunization with myelin antigens. To investigate human immune responses against myelin antigens in vivo we established a new subclinical experimental autoimmune encephalomyelitis model in humanized mice. NOD/Scidγc−/− animals were transferred with peripheral blood mononuclear cells from healthy human donors and immunized with myelin… 
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