Subclassifying chronic fatigue syndrome through exercise testing.

@article{VanNess2003SubclassifyingCF,
  title={Subclassifying chronic fatigue syndrome through exercise testing.},
  author={J Mark VanNess and Christopher R. Snell and David R. Strayer and Line Dempsey and Staci R. Stevens},
  journal={Medicine and science in sports and exercise},
  year={2003},
  volume={35 6},
  pages={
          908-13
        }
}
PURPOSE The purpose of this study was to examine physiological responses of persons with chronic fatigue syndrome (CFS) to a graded exercise test. METHODS Cardiopulmonary exercise tests were performed on 189 patients diagnosed with CFS. Based on values for peak oxygen consumption, patients were assigned to one of four impairment categories (none, mild, moderate, and severe), using American Medical Association (AMA) guidelines. A one-way MANOVA was used to determine differences between… 

Tables from this paper

Properties of measurements obtained during cardiopulmonary exercise testing in individuals with myalgic encephalomyelitis/chronic fatigue syndrome.

CPET measurements demonstrate adequate responsiveness and reproducibility for research and clinical applications and demonstrated moderate to high reliability for individuals with ME/CFS.

Discriminative Validity of Metabolic and Workload Measurements for Identifying People With Chronic Fatigue Syndrome

It might be concluded that a single exercise test is insufficient to reliably demonstrate functional impairment in people with CFS and a second test might be necessary to document the atypical recovery response and protracted fatigue possibly unique to CFS, which can severely limit productivity in the home and workplace.

Diminished Cardiopulmonary Capacity During Post-Exertional Malaise

AbstractReduced functional capacity and post-exertional malaise following physical activity are hallmark symptoms of Chronic Fatigue Syndrome (CFS). That these symptoms are often delayed may explain

Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS).

The results implicate abnormal immune activity in the pathology of exercise intolerance in CFS and are consistent with a channelopathy involving oxidative stress and nitric oxide-related toxicity.

Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome

Low oxygen uptake by muscle cells causes exercise intolerance in a majority of CFS patients, indicating insufficient metabolic adaptation to incremental exercise, and the high increase of the cardiac output relative to the increase of oxygen uptake argues against deconditioning as a cause for physical impairment in these patients.

Physiological Responses to Arm and Leg Exercise in Women Patients with Chronic Fatigue Syndrome

Cardiopulmonary exercise testing is a valid procedure for determining functional capacity in patients with CFS and the majority of values achieved at peak exhaustive exercise were significantly lower in CFS patients than controls.

Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

The purposes of this review are to define CI and discuss its applications to clinical populations, summarize existing data regarding heart rate responses to exercise obtained during maximal CPET in people with ME/CFS, and discuss how trends related to CI observed in the literature should influence future patho-etiological research designs and clinical practice.

Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Evidence to date indicates that ME/CFS patients are uniquely unable to reproduce CPET measures during a second test, despite giving maximal effort during both tests, due to the effects of PEM on energy production.

Physiological factors limiting exercise performance in CFS.

  • T. Noakes
  • Psychology
    Medicine and science in sports and exercise
  • 2004
Vanness et al. (8) propose that persons with chronic fatigue syndrome (CFS) can be classified into different categories according to their V̇O2max values. Since subjects with “mild” to “severe” CFS

Post-exertional symptoms distinguish myalgic encephalomyelitis/chronic fatigue syndrome subjects from healthy controls.

A standardized exertional stimulus produced prolonged, diverse symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects, providing clues to the underlying pathophysiology of ME/CFS, leading to improved diagnosis and treatment.
...

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