Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells.

@article{Bruserud2007SubclassificationOP,
  title={Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells.},
  author={\Oystein Bruserud and Anita Ryningen and Astrid Marta Olsnes and Laila Stordrange and Anne Margrete \Oyan and Karl Henning Kalland and Bj\orn Tore Gjertsen},
  journal={Haematologica},
  year={2007},
  volume={92 3},
  pages={332-41}
}
BACKGROUND AND OBJECTIVES Chemokines are soluble mediators involved in angiogenesis, cellular growth control and immunomodulation. In the present study we investigated the effects of various chemokines on proliferation of acute myelogenous leukemia (AML) cells and constitutive chemokine release by primary AML cells. DESIGN AND METHODS Native human AML cells derived from 68 consecutive patients were cultured in vitro. We investigated AML cell proliferation (3H-thymidine incorporation, colony… CONTINUE READING

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