Subclassification of Tumor Extension and Nodal Metastasis in Papillary Thyroid Cancer to Improve Prognostic Accuracy of the Eighth Edition of the Tumor–Node–Metastasis Classification

@article{Ito2019SubclassificationOT,
  title={Subclassification of Tumor Extension and Nodal Metastasis in Papillary Thyroid Cancer to Improve Prognostic Accuracy of the Eighth Edition of the Tumor–Node–Metastasis Classification},
  author={Yasuhiro Ito and Akira Miyauchi and Minoru Kihara and Hiroo Masuoka and Takuya Higashiyama and Akihiro Miya},
  journal={World Journal of Surgery},
  year={2019},
  volume={44},
  pages={336-345}
}
Background The eighth edition of the tumor–node–metastasis classification system (TNM-8th) reflects the prognosis of papillary thyroid cancer (PTC) better than the seventh edition. This study investigated methods to further improve the prognostic accuracy of the TNM-8th. Methods We enrolled 5683 patients who underwent surgery for PTC at the Kuma Hospital. We subdivided tumor extension (T4a) into T4a1 and T4a2 based on intraoperative gross findings and N1 according to size ( < 3 cm and ≥ 3 cm… 
5 Citations
Prognostic Value of Extranodal Tumor Extension in Papillary Thyroid Carcinoma: Proposal for Upstaging of Cases with Extranodal Tumor Extension
TLDR
The prognostic significance of extranodal tumor extension (LNEx) in PTC is investigated and LNEx-positive patients younger than 55 years in Stage I and those aged 55 or older in Stage II are re-staged to II and III, respectively.
The Role of Tumor and Lymph Node Size and Extension in Papillary Thyroid Cancer Staging
  • H. Mazeh
  • Medicine
    World Journal of Surgery
  • 2019
TLDR
It is brought to the attention of the readers that intraoperative findings need to be considered as vital for thyroid cancer staging and this approach cannot be overstated.
Impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to the American Joint Committee on Cancer eighth edition.
TLDR
The results indicate that the progression of aerodigestive tract infiltration has an impact on the incidence of distant recurrence, and the presence of T4b disease has animpact on the occurrence of distant and locoregional recurrences.
Detailed characterization of metastatic lymph nodes improves the prediction accuracy of currently used risk stratification systems in N1 stage papillary thyroid cancer.
TLDR
The combination of currently used risk stratification systems with detailed characterization of MLNs may improve the predictive accuracy for recurrence/progression in N1 PTC patients.
Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer
TLDR
This work aimed to explore potential diagnostic and prognostic value of systematic inflammatory markers (SIMs) in ATC and aDTC.

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