Subclass distribution of human antibodies to Haemophilus influenzae type b capsular polysaccharide.

@article{Shackelford1987SubclassDO,
  title={Subclass distribution of human antibodies to Haemophilus influenzae type b capsular polysaccharide.},
  author={Penelope G. Shackelford and Dan M Granoff and Susan J. Nelson and Monisha G. Scott and Diana S. Smith and Moon H. Nahm},
  journal={Journal of immunology},
  year={1987},
  volume={138 2},
  pages={587-92}
}
The polysaccharide (PS) capsule of Haemophilus influenzae type b (Hib) is a "simple" antigen, polyribosylribitolphosphate. Although similar carbohydrate antigens have been reported to elicit IgG antibodies relatively restricted to the IgG2 subclass in man, we report here that Hib PS elicits substantial quantities of both IgG1 and IgG2 serum antibodies in most individuals. Because the determination of IgG subclass distribution can be technically difficult, we used four different approaches to… CONTINUE READING
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