Subchronic treatment with antiepileptic drugs modifies pentylenetetrazol-induced seizures in mice: Its correlation with benzodiazepine receptor binding

@article{Rocha2008SubchronicTW,
  title={Subchronic treatment with antiepileptic drugs modifies pentylenetetrazol-induced seizures in mice: Its correlation with benzodiazepine receptor binding},
  author={Luisa L. Rocha},
  journal={Neuropsychiatric Disease and Treatment},
  year={2008},
  volume={4},
  pages={619 - 625}
}
  • Luisa L. Rocha
  • Published 2008 in Neuropsychiatric disease and treatment
Experiments using male CD1 mice were carried out to investigate the effects of subchronic (daily administration for 8 days) pretreatments with drugs enhancing GABAergic transmission (diazepam, 10 mg/kg, ip; gabapentin, 100 mg/kg, po; or vigabatrin, 500 mg/kg, po) on pentylenetetrazol (PTZ)-induced seizures, 24 h after the last injection. Subchronic administration of diazepam reduced latencies to clonus, tonic extension and death induced by PTZ. Subchronic vigabatrin produced enhanced latency to… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 64 references

The lack of CB1 receptors

  • V 36830–9. Warnault, H Houchi, E Barbier
  • 2007

Mechanisms of the antinociceptive action of gabapentin

  • JK Cheng, Chiou LC.
  • J Pharmacol Sci, 100:471–86.
  • 2006

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