Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABA(A) receptor binding.

Abstract

Phencyclidine (PCP), an antagonist at the N-methyl-D-aspartate subtype of ionotropic glutamatergic receptors, decreases gamma-aminobutyric acid (GABA)ergic inhibition, suggesting that changes in GABAergic receptor function underlie behavioral and cognitive deficits resulting from repeated administration of PCP. To test this hypothesis, male Sprague-Dawley… (More)
DOI: 10.1097/FBP.0b013e3283347091

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@article{Beninger2010SubchronicPI, title={Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABA(A) receptor binding.}, author={Richard J. Beninger and Jonathan Beuk and Tomek Jan Banasikowski and Michael van Adel and Gregory A Boivin and James N. Reynolds}, journal={Behavioural pharmacology}, year={2010}, volume={21 1}, pages={1-10} }