Subchronic oral toxicity study on the three flavouring substances: octan-3-ol, 2-methylcrotonic acid and oct-3-yl 2-methylcrotonate in Wistar rats.

@article{Lindecrona2003SubchronicOT,
  title={Subchronic oral toxicity study on the three flavouring substances: octan-3-ol, 2-methylcrotonic acid and oct-3-yl 2-methylcrotonate in Wistar rats.},
  author={Rikke Hvid Lindecrona and A-M M\olck and J\orn Gry and Morten M\oller Poulsen and Rikke Andersen and Inger Thorup},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2003},
  volume={41 5},
  pages={647-54}
}
Groups of 10 male and 10 female rats were administered 0, 25, 100 or 400 mg octan-3-ol/kg body weight per day, 77 mg 2-methylcrotonic acid/kg body weight per day or 163 mg oct-3-yl 2-methylcrotonate/kg body weight per day by gavage for 90 days. Relative liver weights of high-dose octan-3-ol males, and males and females dosed with oct-3-yl 2-methylcrotonate were significantly greater than those of the control. In male and female rats dosed with the highest level of octan-3-ol and in male rats… CONTINUE READING

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