Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease.

@article{Filali2011SubchronicMA,
  title={Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease.},
  author={M. Maskani Filali and Robert Lalonde and Serge Rivest},
  journal={Neuropharmacology},
  year={2011},
  volume={60 6},
  pages={930-6}
}
Glutamate neurotoxicity has been proposed to be involved in Alzheimer pathogenesis, with clinical data supporting successful treatment with the NMDA receptor antagonist memantine. In the present study, the effects of subchronic memantine administration were assessed on spatial and non-spatial learning as well as exploratory activity and nest-building in APP… CONTINUE READING