Subchronic hepatotoxicity evaluation of hydrazobenzene in Fischer 344 rats.

@article{Dodd2012SubchronicHE,
  title={Subchronic hepatotoxicity evaluation of hydrazobenzene in Fischer 344 rats.},
  author={Darol E. Dodd and Linda J. Pluta and Mark A. Sochaski and Henry G Wall and Russell S. Thomas},
  journal={International journal of toxicology},
  year={2012},
  volume={31 6},
  pages={564-71}
}
Male F344 rats were exposed to hydrazobenzene (HZB) by dietary feed at concentrations of 0, 5, 20, 80, 200, or 300 ppm for 5 days, 2 weeks, 4 weeks, or 13 weeks duration. End points evaluated included clinical observations, body weights, liver weights, serum chemistry, blood HZB, gross pathology, and liver histopathology. There were no HZB exposure-related clinical signs of toxicity. During study weeks 8 through 13, body weight means in rats of the 300 ppm group were 6% lower compared to… CONTINUE READING
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