Subchronic hepatotoxicity evaluation of hydrazobenzene in Fischer 344 rats.

  title={Subchronic hepatotoxicity evaluation of hydrazobenzene in Fischer 344 rats.},
  author={Darol E. Dodd and Linda J. Pluta and Mark A. Sochaski and Henry G Wall and Russell S. Thomas},
  journal={International journal of toxicology},
  volume={31 6},
Male F344 rats were exposed to hydrazobenzene (HZB) by dietary feed at concentrations of 0, 5, 20, 80, 200, or 300 ppm for 5 days, 2 weeks, 4 weeks, or 13 weeks duration. End points evaluated included clinical observations, body weights, liver weights, serum chemistry, blood HZB, gross pathology, and liver histopathology. There were no HZB exposure-related clinical signs of toxicity. During study weeks 8 through 13, body weight means in rats of the 300 ppm group were 6% lower compared to… CONTINUE READING
2 Citations
12 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 12 references

Chromatographic determination of hydrazobenzene metabolites in rats

  • T Dutkiewicz, J. Szymanska
  • Bromatol Chem Toksykol
  • 1973
Highly Influential
1 Excerpt

Fundamentals of Toxicologic Pathology

  • WM Haschek, CG Rousseaux, MA. Wallig
  • 2010

Histopathology of Preclinical Toxicology Studies: Interpretation and Relevance in Drug Safety Evaluation

  • P. Greaves
  • 2007

Similar Papers

Loading similar papers…