Subchronic exposure to mitragynine, the principal alkaloid of Mitragyna speciosa, in rats.

  title={Subchronic exposure to mitragynine, the principal alkaloid of Mitragyna speciosa, in rats.},
  author={Azadeh Sabetghadam and Surash Ramanathan and Sreenivasan Sasidharan and Sharif Mahsufi Mansor},
  journal={Journal of ethnopharmacology},
  volume={146 3},
ETHNOPHARMACOLOGICAL RELEVANCE Mitragyna speciosa is a popular medicinal plant in Southeast Asia which is commonly used for its morphine-like effects. Although the analgesic properties of Mitragyna speciosa and its ability to ameliorate withdrawal signs after abrupt cessation of opioid abuse are well known, information about the long-term safety of the plant's active compounds is lacking. In this work, we evaluated the effects of sub-chronic exposure to mitragynine, the principal alkaloid of… CONTINUE READING
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