Subchronic application of humic acids and associated compounds provokes histological changes of goitre in the rat.


1. Different preparations of humic acids, a pyrogallol oxydation product (PYROP) and resorcinol were administered to male and female rats with the drinking water for 8 to 14 weeks. 2. By histometrical evaluation of the thyroid glands, an increase of the mean epithelial cell height of follicular epithelial cells was established in the 0.1% humic acid groups… (More)


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