Subchronic and chronic inhalation toxicity of antimony trioxide in the rat.

@article{Newton1994SubchronicAC,
  title={Subchronic and chronic inhalation toxicity of antimony trioxide in the rat.},
  author={Paul E Newton and Henry F Bolte and Ira Daly and B D Pillsbury and J B Terrill and Robert S. Tripp Lionel Galway Paul S. Killingsworth Eric Drew and R. Ben-Dyke and Amy Sheldon and Lionel F Rubin},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1994},
  volume={22 4},
  pages={561-76}
}
Fischer 344 rats were exposed by inhalation to Sb2O3 (antimony trioxide) dust at exposure levels of 0, 0.25, 1.08, 4.92, and 23.46 mg/m3 for 6 hr/day, 5 days/week for 13 weeks followed by a 27-week observation period. Subsequently, an inhalation oncogenicity study was conducted at exposure levels of 0, 0.06, 0.51, and 4.50 mg/m3 for 12 months followed by a 12-month observation period. The Sb2O3 in the subchronic study had a mass median aerodynamic diameter (MMAD) of 3.05 +/- 0.21 microns (mean… CONTINUE READING