Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression.

  title={Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression.},
  author={Aida Salameh and Christian Frenzel and Andreas Boldt and Beate Rassler and I Glawe and Jutta Schulte and Katja M{\"u}hlberg and H-G Zimmer and Dietrich Pfeiffer and Stefan Dhein},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={20 2},
Gap junction channels are essential for intercellular electrical communication in the heart. The most important cardiac gap junction proteins are connexin43 (predominantly) (Cx43), connexin40 (Cx40), and in early developmental stages connexin45. Since catecholamines play an important role in cardiac (patho)physiology, we wanted to elucidate whether catecholamines may affect expression of Cx43 and Cx40. Cultured neonatal rat cardiomyocytes were exposed for 24 h to increasing concentrations of… CONTINUE READING


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Differential regulation of gap junction proteins Connexin 40 and Connexin 43 in cardiomyocytes

  • A. Salameh, K. Mühlberg, P. Schneider, S. Dhein, D. Pfeiffer
  • Intl J Pharmacol
  • 2005
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