Subchronic Treatment with Methamphetamine and Phencyclidine Differentially Alters the Adenosine A1 and A2A Receptors in the Prefrontal Cortex, Hippocampus, and Striatum of the Rat

@article{Shirayama2001SubchronicTW,
  title={Subchronic Treatment with Methamphetamine and Phencyclidine Differentially Alters the Adenosine A1 and A2A Receptors in the Prefrontal Cortex, Hippocampus, and Striatum of the Rat},
  author={Yukihiko Shirayama and Kenji Hashimoto and Teruhiko Higuchi and Yoshio Minabe},
  journal={Neurochemical Research},
  year={2001},
  volume={26},
  pages={363-368}
}
Subchronic treatment with MAP (4.6 mg/kg, i.p., once daily for 11 days) significantly decreased the Kd, but not Bmax, values of [3H]1,3-dipropyl-8-cyclopentylxanthine ([3H]DPCPX) binding to adenosine A1 receptors in the prefrontal cortex and hippocampus, but not striatum, of rat brain. However, subchronic treatment with PCP (10 mg/kg, i.p., once daily for 11 days) did not alter the Kd and Bmax values of [3H]DPCPX binding to adenosine A1 receptors in these three regions. Subchronic treatment… CONTINUE READING