Subchronic Pulmonary Pathology, Iron Overload, and Transcriptional Activity after Libby Amphibole Exposure in Rat Models of Cardiovascular Disease

@inproceedings{Shannahan2012SubchronicPP,
  title={Subchronic Pulmonary Pathology, Iron Overload, and Transcriptional Activity after Libby Amphibole Exposure in Rat Models of Cardiovascular Disease},
  author={Jonathan Henry Shannahan and Abraham Nyska and Mark A Cesta and Mette C.J. Schladweiler and Beena D. Vallant and William O. Ward and Andrew J Ghio and Stephen H. Gavett and Urmila P Kodavanti},
  booktitle={Environmental health perspectives},
  year={2012}
}
BACKGROUND Surface-available iron (Fe) is proposed to contribute to asbestos-induced toxicity through the production of reactive oxygen species. OBJECTIVE Our goal was to evaluate the hypothesis that rat models of cardiovascular disease with coexistent Fe overload would be increasingly sensitive to Libby amphibole (LA)-induced subchronic lung injury. METHODS Male healthy Wistar Kyoto (WKY), spontaneously hypertensive (SH), and SH heart failure (SHHF) rats were intratracheally instilled with… CONTINUE READING