Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs.

  title={Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs.},
  author={Ben A R Lina and Albert B{\"a}r},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={39 Suppl 1},
The oral toxicity of alpha-cyclodextrin (alpha-CD) was examined in a 13-week feeding study in which groups of Beagle dogs received alpha-CD in the diet at concentrations of 0 (control), 5, 10, or 20% (4 dogs/sex/group). No treatment-related changes were noted in behavior or appearance of the dogs and no mortalities occurred. Diarrhea occurred in all alpha-CD groups. The incidence and severity of diarrhea increased with increasing dietary levels of alpha-CD and was more pronounced in males than… CONTINUE READING