Subchronic (13-week) inhalation toxicity study of formaldehyde in rats.

  title={Subchronic (13-week) inhalation toxicity study of formaldehyde in rats.},
  author={Ruud A. Woutersen and L M Appelman and J W Wilmer and Hein E. Falke and Victor J. Feron},
  journal={Journal of applied toxicology : JAT},
  volume={7 1},
Male and female albino Wistar rats were exposed to concentrations of 0, 1, 10 or 20 ppm formaldehyde vapour during 6 h/day, 5 days/wk for 13 weeks. Treatment-related changes observed at 20 ppm included in both sexes: stared coats, uncoordinated locomotion and excitation during the first 30 minutes of each exposure, yellowing of the fur, growth retardation, a decreased level of plasma protein, severe and extensive karatinized stratified squamous metaplasia of the nasal respiratory epithelium… CONTINUE READING
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