Subcellular targets of cisplatin cytotoxicity: an integrated view.

  title={Subcellular targets of cisplatin cytotoxicity: an integrated view.},
  author={Sandra M. Sancho-Mart{\'i}nez and Laura Prieto-Garc{\'i}a and Marta P{\'e}rez Prieto and Jos{\'e} Miguel L{\'o}pez-Novoa and Francisco J. Lopez-Hernandez},
  journal={Pharmacology & therapeutics},
  volume={136 1},
Cisplatin is a chemotherapeutic drug widely used against a variety of cancers. Its clinical utility is severely limited by its toxicity, which mainly affects, but is not limited to, the inner ear and renal tubules. Cisplatin toxicity is determined by target tissue and cell accumulation, subcellular handling and trafficking through diverse subcellular… CONTINUE READING