Subcellular targeting strategies for drug design and delivery

  title={Subcellular targeting strategies for drug design and delivery},
  author={Lawrence Rajendran and Hans-Joachim Kn{\"o}lker and Kai Simons},
  journal={Nature Reviews Drug Discovery},
Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design. In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to… CONTINUE READING

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