Subcellular stress response and induction of molecular chaperones and folding proteins after transient global ischemia in rats

@article{Truettner2009SubcellularSR,
  title={Subcellular stress response and induction of molecular chaperones and folding proteins after transient global ischemia in rats},
  author={Jessie S. Truettner and Kurt Hu and Cindy Lin Liu and W. Dalton Dietrich and Bingren Hu},
  journal={Brain Research},
  year={2009},
  volume={1249},
  pages={9-18}
}
Brain ischemia induces the toxic accumulation of unfolded proteins in vulnerable neurons. This cellular event can trigger the unfolded protein response (UPR) and activate the expression of a number of genes involved in pro-survival pathways. One of the pro-survival pathways involves the sequestration and elimination of misfolded and aggregated proteins. Recent evidence suggests that the endoplasmic reticulum (ER), mitochondria, and cytoplasm respond individually to the accumulation of unfolded… CONTINUE READING

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