Subcellular renal proximal tubular mitochondrial toxicity with tenofovir treatment.

Abstract

Nucleoside reverse transcriptase inhibitors (NRTIs) are drugs used in the treatment of HIV/AIDS. Despite the distinct benefits of NRTI-based therapies, tissue specific toxicity is a limiting factor. Although the mechanisms of these specific antiretroviral drug-related toxicities remain unclear, it has been hypothesized that as analogs to native nucleosides… (More)
DOI: 10.1007/978-1-61779-163-5_22

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