Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV.

@article{Guan2012SubcellularRO,
  title={Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV.},
  author={Yingjie Guan and Qian Chen and Xu Yang and P. E. Haines and Ming Pei and Richard M. Terek and Xiao-chun Wei and Tingcun Zhao and Lei Wei},
  journal={American journal of physiology. Cell physiology},
  year={2012},
  volume={303 1},
  pages={C33-40}
}
Regulatory mechanisms of chondrocyte differentiation in the growth plate are incompletely understood. Here, we find that histone deacetylase 4 (HDAC4) is located in the nucleus of chondrocytes in the proliferation zone and relocates to the cytoplasm of chondrocytes in the prehypertrophic zone in vivo. This suggests that the relocation of HDAC4 from the nucleus to the cytoplasm may play a role during chondrocyte differentiation. Expression of active CaMKIV in chondrocytes promotes HDAC4… CONTINUE READING