Subcellular redistribution and mitotic inheritance of transition metals in proliferating mouse fibroblast cells.

@article{McRae2013SubcellularRA,
  title={Subcellular redistribution and mitotic inheritance of transition metals in proliferating mouse fibroblast cells.},
  author={Reagan L McRae and Barry Lai and Christoph J Fahrni},
  journal={Metallomics : integrated biometal science},
  year={2013},
  volume={5 1},
  pages={52-61}
}
Synchrotron X-ray fluorescence microscopy of non-synchronized NIH 3T3 fibroblasts revealed an intriguing redistribution dynamics that defines the inheritance of trace metals during mitosis. At metaphase, the highest density areas of Zn and Cu are localized in two distinct regions adjacent to the metaphase plate. As the sister chromatids are pulled towards the spindle poles during anaphase, Zn and Cu gradually move to the center and partition into the daughter cells to yield a pair of twin pools… CONTINUE READING

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