Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.


Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons, yet little is known about their subcellular distribution or, specifically, which transcripts are in growth cones. Here laser capture microdissection (LCM) was used to isolate the growth cones of retinal ganglion cell… (More)
DOI: 10.1523/JNEUROSCI.1800-10.2010


10 Figures and Tables