Subcellular mobility of the calpain/calpastatin network: an organelle transient.

@article{Hood2006SubcellularMO,
  title={Subcellular mobility of the calpain/calpastatin network: an organelle transient.},
  author={Joshua L Hood and William H. Brooks and Thomas L. Roszman},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2006},
  volume={28 8},
  pages={
          850-9
        }
}
Calpain (Cp) is a calcium (Ca(2+))-dependent cysteine protease. Activation of the major isoforms of Cp, CpI and CpII, are required for a number of important cellular processes including adherence, shape change and migration. The current concept that cytoplasmic Cp locates and associates with its regulatory subunit (Rs) and substrates as well as translocates throughout the cell via random diffusion is not compatible with the spatial and temporal constraints of cellular metabolism. The novel… CONTINUE READING
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