Subcellular localization of the MNV-1 ORF1 proteins and their potential roles in the formation of the MNV-1 replication complex.

@article{Hyde2010SubcellularLO,
  title={Subcellular localization of the MNV-1 ORF1 proteins and their potential roles in the formation of the MNV-1 replication complex.},
  author={Jennifer L. Hyde and Jason M Mackenzie},
  journal={Virology},
  year={2010},
  volume={406 1},
  pages={138-48}
}
Human noroviruses are the leading cause of nonbacterial gastroenteritis worldwide and are now recognised as a significant human pathogen. Whereas human noroviruses cannot be cultivated in the laboratory, mouse norovirus 1 (MNV-1) is easily cultivated and has a defined tropism for cells of a mononuclear origin. As such, MNV-1 provides an ideal opportunity to study many aspects of norovirus biology and replication. Previously, we have shown that MNV-1 RNA replication is associated with components… CONTINUE READING
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