Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.

@article{Brooks2000SubcellularLO,
  title={Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.},
  author={Paul Brooks and Graciela Fuertes and Rachael Z Murray and Suchira Bose and Erwin Knecht and Martin Rechsteiner and Klavs B. Hendil and Kunihiko Tanaka and Julian P. Dyson and Jasmine P H Rivett},
  journal={The Biochemical journal},
  year={2000},
  volume={346 Pt 1},
  pages={155-61}
}
Proteasomes can exist in several different molecular forms in mammalian cells. The core 20S proteasome, containing the proteolytic sites, binds regulatory complexes at the ends of its cylindrical structure. Together with two 19S ATPase regulatory complexes it forms the 26S proteasome, which is involved in ubiquitin-dependent proteolysis. The 20S proteasome can also bind 11S regulatory complexes (REG, PA28) which play a role in antigen processing, as do the three variable gamma-interferon… CONTINUE READING

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