Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells.

@article{Kryl1999SubcellularLO,
  title={Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells.},
  author={D Kryl and Talene Alene Yacoubian and Annakaisa Haapasalo and Eero Castr{\'e}n and David Lo and Phillip A Barker},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 14},
  pages={5823-33}
}
Neurotrophins affect neuronal development and plasticity via spatially localized effects, yet little is known about the subcellular distribution of the Trk neurotrophin receptors and the impact of this distribution on neurotrophin action. To address this, we examined the subcellular location of full-length TrkB and TrkC tyrosine kinase receptors and truncated TrkB isoforms after transfection of Madin-Darby canine kidney (MDCK) cells, dissociated primary hippocampal neurons, and cortical neurons… CONTINUE READING
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