Subcellular localization of boron in cultured melanoma cells by electron energy-loss spectroscopy of freeze-dried cryosections.

@article{Michel2003SubcellularLO,
  title={Subcellular localization of boron in cultured melanoma cells by electron energy-loss spectroscopy of freeze-dried cryosections.},
  author={Jean Michel and Wolfgang Sauerwein and Andrea Wittig and G{\'e}rard Balossier and Karl Zierold},
  journal={Journal of microscopy},
  year={2003},
  volume={210 Pt 1},
  pages={25-34}
}
Boron neutron capture therapy (BNCT) is based on the ability of the non-radioactive isotope 10B to capture thermal neutrons and to disintegrate instantaneously. This reaction opens a way to selectively destroy tumour cells after specific uptake of 10B. In this paper, a method based on electron energy-loss spectroscopy is presented for detecting and quantifying boron in freeze-dried cryosections of human melanoma cells. A practical detection limit of around 6 mmol kg-1 in 0.1- micro m2 areas is… CONTINUE READING
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