Subcellular localization and topology of the p7 polypeptide of hepatitis C virus.

  title={Subcellular localization and topology of the p7 polypeptide of hepatitis C virus.},
  author={S{\'e}verine Carr{\`e}re-Kremer and Claire Montpellier-Pala and Laurence Cocquerel and Czeslaw Wychowski and François Penin and Jean Dubuisson},
  journal={Journal of virology},
  volume={76 8},
Although biological and biochemical data have been accumulated on most hepatitis C virus proteins, the structure and function of the 63-amino-acid p7 polypeptide of this virus have never been investigated. In this work, sequence analyses predicted that p7 contains two transmembrane passages connected by a short hydrophilic segment. The C-terminal transmembrane domain of p7 was predicted to function as a signal sequence, which was confirmed experimentally by analyzing the translocation of a… CONTINUE READING
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