Subcellular localization and axonal transport of the survival motor neuron (SMN) protein in the developing rat spinal cord.

@article{Pagliardini2000SubcellularLA,
  title={Subcellular localization and axonal transport of the survival motor neuron (SMN) protein in the developing rat spinal cord.},
  author={Silvia Pagliardini and Alessio Giavazzi and Veronica Setola and C Lizier and Monica di Luca and S Debiasi and Giorgio Battaglia},
  journal={Human molecular genetics},
  year={2000},
  volume={9 1},
  pages={47-56}
}
The subcellular localization of the survival motor neuron (SMN) protein, encoded by the spinal muscular atrophy determining gene, was investigated in motor neurons of the developing and adult rat spinal cord by light and electron microscopy immunocytochemistry. The experiments were carried out with a panel of anti-SMN antibodies, all recognizing an SMN-specific protein band at 39 kDa in HeLa cells and rat spinal cord protein extracts. SMN protein expression decreased during postnatal spinal… CONTINUE READING

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