Subcellular fractionation of stored red blood cells reveals a compartment-based protein carbonylation evolution.

@article{Delobel2012SubcellularFO,
  title={Subcellular fractionation of stored red blood cells reveals a compartment-based protein carbonylation evolution.},
  author={Julien Delobel and Michel Prudent and Olivier Rubin and David Crettaz and Jean-Daniel Tissot and Niels Lion},
  journal={Journal of proteomics},
  year={2012},
  volume={76 Spec No.},
  pages={181-93}
}
During blood banking, erythrocytes undergo storage lesions, altering or degrading their metabolism, rheological properties, and protein content. Carbonylation is a hallmark of protein oxidative lesions, thus of red blood cell oxidative stress. In order to improve global erythrocyte protein carbonylation assessment, subcellular fractionation has been established, allowing us to work on four different protein populations, namely soluble hemoglobin, hemoglobin-depleted soluble fraction, integral… CONTINUE READING
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