Subcellular distribution of epothilones in human tumor cells.

@article{Lichtner2001SubcellularDO,
  title={Subcellular distribution of epothilones in human tumor cells.},
  author={Rosemarie B. Lichtner and Andrea Rotgeri and Thomas Bunte and Bernd Buchmann and Jean-S{\'e}bastien Hoffmann and Wolfgang Schwede and Werner Skuballa and Ulrich E. Klar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 20},
  pages={
          11743-8
        }
}
Epothilones are a new class of natural and potent antineoplastic agents that stabilize microtubules. Although 12,13-epoxide derivatives are potent antiproliferative agents, the activities of the corresponding 12,13-olefin analogs are significantly decreased. These data were confirmed for two new analogs, 6-propyl-EpoB (pEB) and 6-propyl-EpoD (pED), in comparison with the natural compounds EpoB/EpoD, by using human A431, MCF7, and MDR1-overexpressing NCI/Adr cells. By using tritiated pEB/pED… CONTINUE READING

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