Subcellular distribution of di- and tricarboxylates and pH gradients in perfused rat liver.

@article{Soboll1980SubcellularDO,
  title={Subcellular distribution of di- and tricarboxylates and pH gradients in perfused rat liver.},
  author={Sibylle Soboll and R Elbers and Roland Scholz and Hans Walter Heldt},
  journal={Hoppe-Seyler's Zeitschrift fur physiologische Chemie},
  year={1980},
  volume={361 1},
  pages={69-76}
}
The subcellular distribution of malate, 2-oxoglutarate, citrate, aspartate and glutamate and the mitochondrial and cytosolic pH values were determined in perfused livers from fed and fasted rats. The method of fractionation of the freeze-dried tissue in non-aqueous solvents was employed. The following results were obtained: 1) Di- and tricarboxylates are not equally distributed between mitochondria and cytosol. Under the two metabolic conditions studied, the concentrations of citrate and 2… CONTINUE READING