Subcellular distribution of calcium-sensitive potassium channels (IK1) in migrating cells.

  title={Subcellular distribution of calcium-sensitive potassium channels (IK1) in migrating cells.},
  author={Albrecht Schwab and Andrea Wulf and Christoph Schulz and Wolfram Kessler and Volodymyr Nechyporuk-Zloy and Michael R{\"o}mer and J{\"u}rgen Reinhardt and Dietmar Weinhold and Peter Dieterich and Christian M. Stock and Steven C. Hebert},
  journal={Journal of cellular physiology},
  volume={206 1},
Cell migration is crucial for wound healing, immune defense, or formation of tumor metastases. In addition to the cytoskeleton, Ca2+ sensitive K+ channels (IK1) are also part of the cellular "migration machinery." We showed that Ca2+ sensitive K+ channels support the retraction of the rear part of migrating MDCK-F cells by inducing a localized shrinkage at this cell pole. So far the molecular nature and in particular the subcellular distribution of these channels in MDCK-F cells is unknown. We… CONTINUE READING

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