Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon.

@article{Anderson2002SubcellularDO,
  title={Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon.},
  author={Christine B. Anderson and Kristi L Neufeld and Raymond L. White},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 13},
  pages={8683-8}
}
Mutations in the APC tumor suppressor gene are present in approximately 85% of colorectal tumors and are thought to contribute early in the process of tumorigenesis. The truncated protein resulting from most APC mutations can lead to elevated beta-catenin levels in colon tumor cells. APC and associated proteins thus form a beta-catenin regulatory complex, with axin playing a key role. Although cell culture studies have revealed intriguing aspects of this complex, little characterization has… CONTINUE READING
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