Subcellular distribution and turnover of presenilins in transfected cells.

  title={Subcellular distribution and turnover of presenilins in transfected cells.},
  author={Ji-min Zhang and David E. Kang and Weiming Xia and Masayasu Okochi and Hiroshi Mori and Dennis J Selkoe and Edward H. Koo},
  journal={The Journal of biological chemistry},
  volume={273 20},
The mechanisms by which mutations in presenilin-1 (PS1) and presenilin-2 (PS2) result in the Alzheimer's disease phenotype are unclear. Full-length PS1 and PS2 are each processed into stable proteolytic fragments after their biosynthesis in transfected cells. PS1 and PS2 have been localized by immunocytochemistry to the endoplasmic reticulum (ER) and Golgi compartments, but previous studies could not differentiate between the full-length presenilin proteins and their fragments. We carried out… CONTINUE READING

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