Subcellular distribution and early signalling events of P2X7 receptors from mouse cerebellar granule neurons.

@article{SnchezNogueiro2014SubcellularDA,
  title={Subcellular distribution and early signalling events of P2X7 receptors from mouse cerebellar granule neurons.},
  author={Jes{\'u}s S{\'a}nchez-Nogueiro and Patricia Mar{\'i}n-Garc{\'i}a and Diego Bustillo and Luis Alcides Olivos-Or{\'e} and M Teresa Miras-Portugal and Antonio R. Artalejo},
  journal={European journal of pharmacology},
  year={2014},
  volume={744},
  pages={190-202}
}
The subcellular distribution and early signalling events of P2X7 receptors were studied in mouse cerebellar granule neurons. Whole-cell patch-clamp recordings evidenced inwardly directed non-desensitizing currents following adenosine 5'-triphosphate (ATP; 600 µM) or 2'-3'-o-(4-benzoylbenzoyl)-adenosine 5'-triphosphate (BzATP; 100 µM) administration to cells bathed in a medium with no-added divalent cations (Ca(2+) and Mg(2+)). Nucleotide-activated currents were inhibited by superfusion of 2.5… CONTINUE READING