Subcellular distribution, a factor in risk evaluation of pentachlorophenol.

  title={Subcellular distribution, a factor in risk evaluation of pentachlorophenol.},
  author={E K Arrhenius and L. Renberg and L Johansson},
  journal={Chemico-biological interactions},
  volume={18 1},
Pentachlorophenol (PCP) is a potent uncoupler of mitochondrial phosphorylation in vitro and also interferes with microsomal detoxication functions in vitro. This favours flavin mediated oxygenation compared with flavin cytochrome P-450 dependent reactions. Gas chromatographic analysis of subcellular fractions, obtained by zonal centrifugation showed markedly lower PCP concentration in mitochondria and a high accumulation in microsomes compared with cytosol. This increases the likelihood that… CONTINUE READING