Subcellular characterization of the transferrin-transferrin receptor and iron accumulating system of established human erythroid and monoblastoid tumour cell lines.

The organelles in two human tumour cell lines in culture - U-937 and K-562 - involved in the receptor mediated endocytosis (RME) of transferrin (Tf) were studied after isolation from homogenates by density gradient separation. They were also studied by electron microscopy after labelling of living cells with Tf coated colloidal gold particles. Three… CONTINUE READING