Subcellular calcium transients visualized by confocal microscopy in a voltage-clamped vertebrate neuron.

@article{HernndezCruz1990SubcellularCT,
  title={Subcellular calcium transients visualized by confocal microscopy in a voltage-clamped vertebrate neuron.},
  author={Arturo Hern{\'a}ndez-Cruz and Francesco Sala and Paul R. Adams},
  journal={Science},
  year={1990},
  volume={247 4944},
  pages={858-62}
}
Confocal laser-scanned microscopy and long-wavelength calcium (Ca2+) indicators were combined to monitor both sustained and rapidly dissipating Ca2+ gradients in voltage-clamped sympathetic neurons isolated from the bullfrog. After a brief activation of voltage-dependent Ca2+ channels, Ca2+ spreads inwardly, and reaches the center of these spherical cells in about 300 milliseconds. Although the Ca2+ redistribution in the bulk of the cytosol could be accounted for with a radial diffusion model… CONTINUE READING

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